![]() ![]() Major symptoms may include severe itching, hives, flushing, swelling, vomiting, diarrhea, difficulty breathing and unconsciousness. Comparisons may be useful for a differential diagnosis:Īnaphylaxis is an abnormally severe allergic reaction to a substance. Symptoms of the following disorders can be similar to those of neuroleptic malignant syndrome. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.Ī genetic basis for the disorder is suspected but not proven. The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine. These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). ![]() Stay Informed With NORD’s Email Newsletter.Find a Rare Disease Patient Organization.Find Clinical Trials & Research Studies.Launching Registries & Natural History Studies.A Podcast For The Rare Disease Community. ![]()
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